Alveolar hypoventilation treated with medroxyprogesterone.

Abstract

Two children aged 1 and 20 months developed alveolar hypoventilation syndrome. They suffered severe apnoeic episodes and periodically required assisted ventilation. Their ventilatory response to carbon dioxide was lower than that of normal children and the transcutaneous oxygen tension during sleep was well below the normal range. Treatment with medroxyprogesterone acetate resulted in an improved response to carbon dioxide, and assisted ventilation was no longer needed. Oxygen and carbon dioxide tensions improved but were still slightly abnormal during sleep. There were no clinical side effects of treatment but one infant had slight pituitary suppression.

• Authors: J Milerad, H Lagercrantz, O Löfgren
• Journal: Archives of disease in childhood (Arch Dis Child) Vol. 60 Issue 2 Pg. 150-5 (Feb 1985) ISSN: 1468-2044 [Electronic] England
• PMID: 3156565 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hormones
• Carbon Dioxide
• Medroxyprogesterone Acetate
• Medroxyprogesterone
• Oxygen

Topics

• Carbon Dioxide (physiology)
• Child Development (drug effects)
• Female
• Hormones (analysis)
• Humans
• Infant
• Infant, Newborn
• Medroxyprogesterone (analogs & derivatives, therapeutic use)
• Medroxyprogesterone Acetate
• Oxygen (physiology)
• Partial Pressure
• Sleep
• Sleep Apnea Syndromes (drug therapy, physiopathology)