Function of ion transporters in maintaining acid-base homeostasis of the mammary gland and the pathophysiological role in breast cancer.

The incidence of breast cancer is increasing year by year, and the pathogenesis is still unclear. Studies have shown that the high metabolism of solid tumors leads to an increase in hypoxia, glycolysis, production of lactic acid and carbonic acid, and extracellular acidification; a harsh microenvironment; and ultimately to tumor cell death. Approximately 50% of locally advanced breast cancers exhibit hypoxia and/or local hypoxia, and acid-base regulatory proteins play an important role in regulating milk secretion and maintaining mammary gland physiological function. Therefore, ion transporters have gradually become a hot topic in mammary gland and breast cancer research. This review focuses on the research progress of ion transporters in mammary glands and breast cancer. We hope to provide new targets for the treatment and prognosis of breast cancer.
AuthorsZhiyuan Ma, Dumin Yuan, Xiaoming Cheng, Biguang Tuo, Xuemei Liu, Taolang Li
JournalAmerican journal of physiology. Regulatory, integrative and comparative physiology (Am J Physiol Regul Integr Comp Physiol) Vol. 318 Issue 1 Pg. R98-R111 (01 01 2020) ISSN: 1522-1490 [Electronic] United States
PMID31553634 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Carrier Proteins
  • Breast Neoplasms (metabolism)
  • Carrier Proteins (genetics, metabolism)
  • Female
  • Homeostasis (physiology)
  • Humans
  • Ion Transport
  • Mammary Glands, Human (physiology)

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