Abstract |
In vivo presensitization of donor mice of responding cells with third party cellular antigens augmented in vitro generation of cytotoxic T lymphocytes in allogeneic and xenogeneic combinations. In vitro induction of detectable cytotoxicity in presensitized responding cells required the incubation period needed for in vitro primary response. However, such cytotoxic T lymphocytes were generated after in vitro stimulation with monolayers of methylcholanthrene-induced tumor cells, UV-irradiated or heated spleen cells which had proved to be effective in secondary but not in primary response. Presensitized responding cells exposed to 600R-irradiation did not augment in vitro induction of cytotoxicity in normal responding cells. The augmenting effect of presensitized responding cells may be attributable to radiosensitive T cells which are in a transitional state in differentiation from typical unprimed cells to typical primed cells.
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Authors | H Yamada, K Nomoto, K Takeya |
Journal | Microbiology and immunology
(Microbiol Immunol)
Vol. 23
Issue 5
Pg. 357-68
( 1979)
ISSN: 0385-5600 [Print] Australia |
PMID | 315508
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Antigens, Neoplasm
(immunology)
- Culture Techniques
- Cytotoxicity, Immunologic
- Female
- Hot Temperature
- Male
- Mice
- Mice, Inbred Strains
- Neoplasm Transplantation
- Rats
- Sarcoma, Experimental
(immunology)
- Spleen
- T-Lymphocytes
(immunology, radiation effects)
- Ultraviolet Rays
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