Presence of lymphocyte membrane surface markers on "small cells" in a pineal germinoma.

Abstract

A 16-year-old boy was operated on via an occipital transtentorial craniotomy for a pineal tumor. Routine histological examination of the tissue revealed it to be a germinoma, as characterized by the presence of two cell populations: large cells and small, lymphoid-appearing cells. The cells were evaluated in a single-cell suspension for the presence of lymphocyte membrane surface markers; small cells exclusively were found to have such markers. A T-lymphocyte membrane marker was present in 51% of the small cells, whereas 15 to 18% of the small cells had a B-lymphocyte membrane marker.

• Authors: E A Neuwelt, R G Smith
• Journal: Annals of neurology (Ann Neurol) Vol. 6 Issue 2 Pg. 133-6 (Aug 1979) ISSN: 0364-5134 [Print] United States
• PMID: 315205 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunoglobulins

Topics

• Adolescent
• B-Lymphocytes
• Brain Neoplasms (immunology, pathology)
• Humans
• Immunoglobulins (analysis)
• Male
• Pineal Gland
• Pinealoma (immunology, pathology)
• Rosette Formation
• T-Lymphocytes