Periodic alternating nystagmus.

Horizontal jerk nystagmus is indicative of a disorder involving the vestibular system. Periodic alternating nystagmus is a form of spontaneous nystagmus with a specific pattern. It is identified by the presence of spontaneous nystagmus in the primary direction of gaze, which beats in one direction for 1 or 2 minutes, followed by a null period, and then reappearance of the nystagmus in the opposite direction for a similar length of time. It may be congenital or acquired, and may be seen in association with vestibular-cerebellar disease or loss of vision. Recent case reports indicate that some forms of periodic alternating nystagmus may respond favorably to baclofen therapy.
AuthorsJ R DiBartolomeo, R D Yee
JournalOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 99 Issue 6 Pg. 552-7 (Dec 1988) ISSN: 0194-5998 [Print] UNITED STATES
PMID3148116 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Baclofen
  • Baclofen (therapeutic use)
  • Electronystagmography
  • Humans
  • Labyrinth Diseases (physiopathology)
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nystagmus, Pathologic (diagnosis, drug therapy, physiopathology)
  • Periodicity
  • Vestibule, Labyrinth (physiopathology)

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