[Anticonvulsant properties of the cerebrospinal fluid during activation of the antiepileptic system of the brain].

Abstract

Cerebrospinal fluid (CSF) was obtained after 30-40 sessions of daily electrical stimulation of the cat cerebellum vermis. The intraventricular injection of CSF (10 microliters) to Wistar rats increased the latent period of initial seizure manifestations, significantly reduced the number of animals with seizures and reduced the severity of seizures induced by korazol injection (40 mg/kg). Analogous seizure changes were observed in rats after intraventricular injection of CSF (10 microliters) from cats subject to 3-10 electroshock seizure fits. Intraventricular injection of CSF (250 microliters) obtained from cats after electroshock to cats with strychnine-induced epileptic foci in the brain cortex led to the suppression of the epileptic activity. The conclusion was made that different ways of antiepileptic system activation cause the accumulation of endogenous antiepileptic substances in CSF.

• Authors: G N Kryzhanovskiĭ, A A Shandra, L S Godlevskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 106 Issue 8 Pg. 146-9 (Aug 1988) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Protivosudorozhnye svoĭstva likvora pri aktivatsii antiépileticheskoĭ sistemy mozga.
• PMID: 3137978 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Pentylenetetrazole

Topics

• Animals
• Cats
• Cerebellar Cortex (physiology)
• Electrodes, Implanted
• Electroshock
• Epilepsies, Partial (cerebrospinal fluid, physiopathology, prevention & control)
• Epilepsy (cerebrospinal fluid, physiopathology, prevention & control)
• Female
• Injections, Intraventricular
• Male
• Microinjections
• Pentylenetetrazole (pharmacology)
• Rats
• Rats, Inbred Strains
• Time Factors