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Serum sickness with acquired precipitating antibodies during rush immunotherapy (2 cases).

Abstract
Serum sickness can be induced by several heterologous proteins. Two patients undergoing rush immunotherapy developed clinical symptoms of serum sickness. One patient received a mite and grass pollens mixture and the second patient a wasp and yellow-jacket venoms mixture. Precipitating antibodies against some allergens used for immunotherapy were found in their serum during the disease but not in the sera drawn before immunotherapy and two and three months after. Pathologic findings showed a leukocytoclastic vasculitis. Pathogenesis of this complication is discussed.
AuthorsM H Chabane, F Leynadier, G M Halpern, J Dry
JournalAnnals of allergy (Ann Allergy) Vol. 61 Issue 3 Pg. 216-9 (Sep 1988) ISSN: 0003-4738 [Print] United States
PMID3137849 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies
Topics
  • Antibodies (analysis)
  • Biopsy
  • Humans
  • Immunodiffusion
  • Immunotherapy (adverse effects, methods)
  • Male
  • Middle Aged
  • Serum Sickness (etiology, immunology, pathology)
  • Skin (pathology)
  • Time Factors

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