Prospective randomized comparative trial of pefloxacin versus cotrimoxazole in the treatment of typhoid fever in adults.

Pefloxacin, which has been shown to have a high in vitro activity against Salmonella spp., was compared to cotrimoxazole in the treatment of typhoid fever in adults. In a prospective, randomized trial, 42 patients with bacteriologically documented typhoid fever received either 400 mg pefloxacin b.i.d. or 160/800 mg cotrimoxazole b.i.d. Duration of treatment was 14 days in both groups. All patients were cured without experiencing a relapse or becoming a salmonella carrier. Apyrexia and resolution of digestive and neurological symptoms were obtained in a significantly shorter time with pefloxacin than with cotrimoxazole. Pefloxacin was well tolerated and more effective than cotrimoxazole in the treatment of typhoid fever.
AuthorsM Hajji, N el Mdaghri, M Benbachir, K M el Filali, H Himmich
JournalEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 7 Issue 3 Pg. 361-3 (Jun 1988) ISSN: 0934-9723 [Print] GERMANY, WEST
PMID3137036 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Drug Combinations
  • Pefloxacin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Sulfamethoxazole
  • Norfloxacin
  • Adult
  • Drug Combinations (pharmacology, therapeutic use)
  • Female
  • Humans
  • Male
  • Norfloxacin (analogs & derivatives, pharmacology, therapeutic use)
  • Paratyphoid Fever (drug therapy)
  • Pefloxacin
  • Prospective Studies
  • Random Allocation
  • Salmonella paratyphi A (drug effects, isolation & purification)
  • Salmonella paratyphi B (drug effects, isolation & purification)
  • Salmonella typhi (drug effects, isolation & purification)
  • Sulfamethoxazole (pharmacology, therapeutic use)
  • Trimethoprim (pharmacology, therapeutic use)
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Typhoid Fever (drug therapy)

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