Valproate in the treatment of absence epilepsy in children: a study of dose-response relationships.

Abstract

Seven children with absence epilepsy were treated with valproate (VPA). All but one child became free of absence seizures during VPA monotherapy. EEG was recorded for 24 h before start of VPA treatment and repeatedly during treatment. Correlation between plasma VPA concentration and reduction of the number of epileptic discharges was significant. Plasma concentration of 440-660 microM VPA was needed to achieve at least 50% reduction of seizure activity.

• Authors: G Braathen, K Theorell, A Persson, A Rane
• Journal: Epilepsia (Epilepsia) 1988 Sep-Oct Vol. 29 Issue 5 Pg. 548-52 ISSN: 0013-9580 [Print] United States
• PMID: 3137019 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Valproic Acid

Topics

• Adolescent
• Child
• Dose-Response Relationship, Drug
• Epilepsy, Absence (blood, drug therapy)
• Female
• Humans
• Male
• Valproic Acid (blood, therapeutic use)