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Nocturnal asthma: effects of slow-release terbutaline on spirometry and arterial blood-gases.

Abstract
The effect of terbutaline, in a slow-release preparation, on spirometry and arterial blood-gases, was studied in fourteen patients with nocturnal asthma. The patients were treated with either 15 mg of slow-release terbutaline or placebo given as a single dose at 10 pm for eight days in a double-blind crossover trial. The patients were studied in the hospital for one night at the end of each treatment period. During active treatment the patients had a significantly higher FEV1 and PaO2 compared with placebo. Tolerance to the high single dose was good and none of the patients discontinued treatment because of side-effects. In patients with nocturnal asthma treatment with a high dose of slow-release terbutaline given as a single dose in the evening appears to be effective.
AuthorsL Eriksson, B Jonson, G Eklundh, G Persson
JournalThe European respiratory journal (Eur Respir J) Vol. 1 Issue 4 Pg. 302-5 (Apr 1988) ISSN: 0903-1936 [Print] England
PMID3135204 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Delayed-Action Preparations
  • Carbon Dioxide
  • Terbutaline
  • Oxygen
Topics
  • Asthma (drug therapy)
  • Carbon Dioxide (blood)
  • Clinical Trials as Topic
  • Delayed-Action Preparations
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxygen (blood)
  • Spirometry
  • Terbutaline (administration & dosage, therapeutic use)

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