Abstract |
The effect of terbutaline, in a slow-release preparation, on spirometry and arterial blood- gases, was studied in fourteen patients with nocturnal asthma. The patients were treated with either 15 mg of slow-release terbutaline or placebo given as a single dose at 10 pm for eight days in a double-blind crossover trial. The patients were studied in the hospital for one night at the end of each treatment period. During active treatment the patients had a significantly higher FEV1 and PaO2 compared with placebo. Tolerance to the high single dose was good and none of the patients discontinued treatment because of side-effects. In patients with nocturnal asthma treatment with a high dose of slow-release terbutaline given as a single dose in the evening appears to be effective.
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Authors | L Eriksson, B Jonson, G Eklundh, G Persson |
Journal | The European respiratory journal
(Eur Respir J)
Vol. 1
Issue 4
Pg. 302-5
(Apr 1988)
ISSN: 0903-1936 [Print] England |
PMID | 3135204
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Delayed-Action Preparations
- Carbon Dioxide
- Terbutaline
- Oxygen
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Topics |
- Asthma
(drug therapy)
- Carbon Dioxide
(blood)
- Clinical Trials as Topic
- Delayed-Action Preparations
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Oxygen
(blood)
- Spirometry
- Terbutaline
(administration & dosage, therapeutic use)
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