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High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma.

Abstract
A 29-year-old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalcification of bone lesions, and a decrease in the need for antihypertensive treatment for 12 months. Irradiation and combination chemotherapy should be evaluated further in the management of malignant pheochromocytoma.
AuthorsM Z Siddiqui, F E Von Eyben, G Spanos
JournalCancer (Cancer) Vol. 62 Issue 4 Pg. 686-90 (Aug 15 1988) ISSN: 0008-543X [Print] United States
PMID3135110 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Norepinephrine
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Blood Pressure (drug effects)
  • Bone Neoplasms (drug therapy, radiotherapy, secondary)
  • Combined Modality Therapy
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Norepinephrine (blood)
  • Paraplegia (etiology)
  • Pheochromocytoma (drug therapy, radiotherapy, secondary)
  • Radiotherapy, High-Energy

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