Abstract |
Fifty-three patients with metastatic- renal cell carcinoma received treatment with combinations of recombinant alpha (rIFN-alpha-2a) and gamma (rIFN-gamma) interferons on three different treatment schedules. On treatment schedule A, 13 patients received i.m. rIFN-alpha-2a and rIFN-gamma simultaneously at a 1:1 ratio by dose units (2 X 10(6) U/m2), equivalent to a 1:10 ratio by protein weight. Results included severe constitutional symptoms in 62% of the patients and no partial remissions (PR) or complete remissions among 10 evaluable patients. On treatment schedule B, 25 patients received an i.m. injection of rIFN-alpha-2a and rIFN-gamma simultaneously at a 1:1 ratio by protein weight (2 X 10(6) U/m2 and 2 X 10(5) U/m2, respectively). This schedule was well tolerated, allowing a 25-50% increment in over 75% of the patients. Four patients (16%) achieved PR. On treatment schedule C, 15 patients received alternating weekly therapy: first rIFN-gamma (5 X 10(6) U/m2 daily for 7 days) followed by rIFN-alpha-2a (10 X 10(6) U/m2 daily for 7 days). One of 13 evaluable patients in treatment schedule C achieved an 80% tumor reduction and was rendered free of disease after the primary tumor was resected. Toxicity was similar in nature to that of rIFN-alpha-2a or rIFN-gamma separately. The toxicity of treatment schedule A suggested additive toxic effects. No distinct synergistic antitumor effect was observed.
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Authors | J R Quesada, L Evans, S R Saks, J U Gutterman |
Journal | Journal of biological response modifiers
(J Biol Response Mod)
Vol. 7
Issue 3
Pg. 234-9
(Jun 1988)
ISSN: 0732-6580 [Print] United States |
PMID | 3134511
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interferon Type I
- Recombinant Proteins
- Interferon-gamma
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Topics |
- Carcinoma, Renal Cell
(therapy)
- Drug Therapy, Combination
- Female
- Humans
- Immunotherapy
- Interferon Type I
(therapeutic use)
- Interferon-gamma
(therapeutic use)
- Kidney Neoplasms
(therapy)
- Male
- Recombinant Proteins
(therapeutic use)
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