[A case of intrahepatic bile duct cancer responding to 5-fluorouracil, adriamycin and mitomycin C chemotherapy].

Abstract

A 64-year-old woman who was diagnosed as inoperable intrahepatic bile duct cancer with massive liver metastasis was treated with 5-fluorouracil (5-FU), adriamycin (ADM) and mitomycin-C (MMC). Obstructive jaundice was reduced and performance status was soon improved by this regimen. The reduction rate of the tumor was noted to be more than 50% on CT images, so this patient was considered to have achieved a partial response. In histological examination, well differentiated tubular adenocarcinoma cells were degenerated and replaced fibrous tissue. Thus, it was considered that the reduction of the tumor was caused by these phenomena. This case suggested the activity of 5-FU, ADM and MMC combination for bile duct cancer.

• Authors: K Uchiyama, T Takada, H Yasuda, H Hasegawa, S Tsuchiya, Y Misu, Y Saitoh, J Shikata, M Kozakai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 15 Issue 6 Pg. 1987-90 (Jun 1988) ISSN: 0385-0684 [Print] Japan
• PMID: 3132897 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Mitomycins
• Mitomycin
• Doxorubicin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bile Duct Neoplasms (drug therapy)
• Bile Ducts, Intrahepatic
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage)
• Humans
• Middle Aged
• Mitomycin
• Mitomycins (administration & dosage)