Histiocytosis X in two infants--treated with topical nitrogen mustard.

Abstract

Two infants suffering from histiocytosis X were treated successfully with a topically applied nitrogen mustard. All cutaneous symptoms disappeared completely within 2 weeks in one case while the skin improved significantly in the other. No irritation or dermatitis was experienced from the treatment. The only side-effect noted was hyperpigmentation.

• Authors: H Zachariae
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 100 Issue 4 Pg. 433-8 (Apr 1979) ISSN: 0007-0963 [Print] England
• PMID: 313216 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mechlorethamine

Topics

• Administration, Topical
• Child, Preschool
• Female
• Histiocytosis, Langerhans-Cell (drug therapy, pathology)
• Humans
• Infant
• Male
• Mechlorethamine (administration & dosage, therapeutic use)
• Microscopy, Electron
• Skin (ultrastructure)