Pulmonary schistosomiasis mansoni: post-treatment pulmonary clinical-radiological alterations in patients in the chronic phase: a double-blind study.

Abstract

A double blind trial was set up to study the pulmonary effects of specific treatment with oxamniquine of 40 patients with chronic schistosomiasis mansoni. Radiological alterations characterized by bronchopneumonitis were seen in 17.5% of the patients after treatment, but in none of the placebo group; non-migratory condensation occurred between 25 and 72 h after treatment, with a mean duration of 7 d. 86% of the patients showed spontaneous healing with no radiological sequelae after 30 d of follow-up. Slight pulmonary clinical manifestations without any functional repercussions were also seen. The alterations were probably related to the host-parasite interaction, and the lesions may have been caused by deposition of immune complexes in the lungs with local activation of complement.

• Authors: E R Pedroso, J R Lambertucci, D B Greco, O de C Rocha, C S Ferreira, P Raso
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 81 Issue 5 Pg. 778-81 ( 1987) ISSN: 0035-9203 [Print] England
• PMID: 3130687 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitroquinolines
• Oxamniquine

Topics

• Adolescent
• Child
• Clinical Trials as Topic
• Double-Blind Method
• Humans
• Lung (diagnostic imaging, pathology)
• Nitroquinolines (therapeutic use)
• Oxamniquine (therapeutic use)
• Radiography
• Schistosomiasis mansoni (diagnostic imaging, drug therapy, pathology)