An open study of the safety and efficacy of enoxacin in complicated urinary tract infections.

Abstract

Thirty-one patients with serious or complicated urinary tract infections were treated with oral enoxacin for between four and eight days. Twenty-five patients with microbiologically confirmed infections completed treatment with 400 mg enoxacin twice daily and at the end of treatment all urine cultures were negative. At short term follow-up, five to nine days after therapy, 21 of the 25 patients were still infection free. In total, reinfection or relapse occurred in 12 patients during the four to six weeks follow up period after termination of treatment. Significant side-effects (nausea and vomiting) occurred in only one patient.

• Authors: M Foot, G Williams, S Want, M Roe, G Quaghebeur, S Bates
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 21 Suppl B Pg. 97-103 (Feb 1988) ISSN: 0305-7453 [Print] England
• PMID: 3129393 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Naphthyridines
• Enoxacin

Topics

• Adult
• Aged
• Anti-Bacterial Agents (adverse effects, pharmacology, therapeutic use)
• Drug Evaluation
• Enoxacin
• Enterobacteriaceae Infections (drug therapy)
• Enterococcus faecalis (drug effects)
• Escherichia coli (drug effects)
• Female
• Humans
• Male
• Middle Aged
• Naphthyridines (adverse effects, pharmacology, therapeutic use)
• Pseudomonas Infections (drug therapy)
• Pseudomonas aeruginosa (drug effects)
• Streptococcal Infections (drug therapy)
• Urinary Tract Infections (drug therapy)