Abstract |
The expression of interleukin-2 (IL-2) receptor (CD25) has been investigated in 165 cases of hematologic neoplasia by alkaline phosphatase-antialkaline phosphatase (APAAP) labeling of cell smears using two monoclonal anti-IL-2 receptor antibodies (anti-Tac and DAKO-IL2-R). IL-2 receptor was found in 2 of 16 (13%) T-cell malignancies (1 T-ALL, 1 Sézary syndrome). In contrast, among B-cell disorders, IL-2 receptor was expressed in the majority of hairy cell leukemia cases (14 of 16, i.e., 88%) and a smaller proportion of cases of common acute lymphoblastic leukemia (7 of 44, i.e., 16%), B-cell chronic lymphocytic leukemia (8 of 20, i.e., 40%), B-cell prolymphocytic leukemia (3 of 5), and B-cell lymphoma (3 of 8). In addition, IL-2 receptor was present on the neoplastic cells in some cases of acute myeloid leukemia (6 of 44, i.e., 14%) and acute undifferentiated leukemia (4 of 7). IL-2 receptor (Tac antigen) expression is thus found across the spectrum of hematologic neoplasms and is not restricted to T-cell disorders. The explanation for the expression of the IL-2 receptor by such a variety of different hematologic malignancies remains unclear.
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Authors | W N Erber, D Y Mason |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 89
Issue 5
Pg. 645-8
(May 1988)
ISSN: 0002-9173 [Print] England |
PMID | 3128947
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Immunologic
- Receptors, Interleukin-2
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Topics |
- Acute Disease
- Bone Marrow
(metabolism)
- Chronic Disease
- Humans
- Immunoenzyme Techniques
- Leukemia
(metabolism)
- Lymphocytes
(metabolism)
- Lymphoma
(metabolism)
- Lymphoproliferative Disorders
(metabolism)
- Multiple Myeloma
(metabolism)
- Receptors, Immunologic
(analysis)
- Receptors, Interleukin-2
- Sezary Syndrome
(metabolism)
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