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Activity of some naphthoquinones on blood stream forms of Trypanosoma cruzi.

Abstract
Accidental transmission of Chagas disease to man by blood transfusion is a serious problem in Latin America. This paper describes the testing of several naphthoquinones, some of which were active against blood trypomastigotes in vitro at 4 degrees C and might therefore warrant further study for preventing transmission of Chagas disease by blood transfusion.
AuthorsA V Pinto, V F Ferreira, R S Capella, B Gilbert, M C Pinto, J S da Silva
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 81 Issue 4 Pg. 609-10 ( 1987) ISSN: 0035-9203 [Print] England
PMID3127962 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Naphthoquinones
Topics
  • Animals
  • Blood Transfusion
  • Chagas Disease (prevention & control, transmission)
  • Humans
  • Naphthoquinones (pharmacology)
  • Structure-Activity Relationship
  • Trypanosoma cruzi (drug effects)

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