Preliminary report on microencapsulated islet transplantation in experimental diabetes mellitus in China.

Abstract

Pancreatic islets were encapsulated with sodium alginate-polylysine after procurement by collagenase digestion and Ficoll density-gradient-dispersion. The encapsulated islets were intact and during the first week of culture produced insulin 63 +/- 42 microU/d vs 69 +/- 42 microU/d by noncapsulated islets. Seven streptozotocin-induced diabetic rats each received 4.0-4.5 x 10(3) microencapsulated islets intraperitoneally. After transplantation, blood glucose dropped from 350 +/- 29 mg/dl to 142 +/- 12 mg/dl. To date, normoglycemia has been maintained for 222 days. Control animals either died or developed cataracts.

• Authors: Z Wu, Z Lu, A M Sun
• Journal: International journal of pancreatology : official journal of the International Association of Pancreatology (Int J Pancreatol) 1988 Jan-Feb Vol. 3 Issue 1 Pg. 91-100 ISSN: 0169-4197 [Print] United States
• PMID: 3127498 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Capsules

Topics

• Animals
• Blood Glucose (analysis)
• Capsules
• China
• Diabetes Mellitus, Experimental (blood, pathology, surgery)
• Islets of Langerhans (anatomy & histology)
• Islets of Langerhans Transplantation
• Male
• Rats
• Rats, Inbred Strains