Release of opioid peptides from the spinal cord of rats subjected to chronic pain.

Abstract

Chronic localized pain increased the level of the opioid peptides, dynorphin (DYN), alpha-neoendorphin (ANEO), Met-enkephalin (MET) and Mets-enkephalin-Arg6-Gly7-Leu8 (MEAGL), in the lumbar enlargement of the rat spinal cord. It was accompanied with a reduction of the spontaneous and K+-stimulated release of ANEO and MEAGL from spinal cord slices in vitro and a decreased release of ANEO from the spinal cord in vivo. The results indicate that the reduction in the activity of endogenous opioid peptide systems might occur in the spinal cord of rats subjected to chronic pain.

• Authors: R Przewłocki, W Lasoń, J Silberring, A Herz, B Przewłocka
• Journal: NIDA research monograph (NIDA Res Monogr) Vol. 75 Pg. 422-5 ( 1986) ISSN: 1046-9516 [Print] United States
• PMID: 3123959 (Publication Type: Journal Article)

Chemical References

• Endorphins

Topics

• Animals
• Arthritis, Experimental (physiopathology)
• Chronic Disease
• Endorphins (metabolism)
• Male
• Pain (physiopathology)
• Rats
• Rats, Inbred Strains
• Spinal Cord (metabolism, physiopathology)