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Involvement of urokinase-type plasminogen activator in acantholysis induced by pemphigus IgG.

Abstract
Pemphigus IgG induces acantholysis in skin organ culture without the involvement of complement. Urokinase-type plasminogen activator, a proteolytic enzyme, has been implicated in the development of acantholysis. To test this hypothesis, we prepared a rabbit anti-urokinase antibody, which inhibited the plasminogen activator activity in normal human epidermis and in cultured keratinocytes. When added to skin organ cultures along with pemphigus IgG, anti-urokinase IgG completely prevented the development of acantholysis. Normal or preimmune rabbit IgG had no effect on pemphigus IgG-induced acantholysis. Plasminogen activator converts the zymogen plasminogen to its active form plasmin, a broad specificity serine proteinase. When high concentrations of plasminogen alone were added to skin organ culture, acantholysis of the pemphigus foliaceous type was induced. Anti-urokinase antibody also inhibited plasminogen-induced acantholysis. These results strongly support a pivotal role for plasminogen activator in the development of acantholysis.
AuthorsS Morioka, G S Lazarus, P J Jensen
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 89 Issue 5 Pg. 474-7 (Nov 1987) ISSN: 0022-202X [Print] United States
PMID3117905 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Autoantibodies
  • Immunoglobulin G
  • Plasminogen Activators
  • Urokinase-Type Plasminogen Activator
Topics
  • Acantholysis (etiology, immunology, physiopathology)
  • Adult
  • Animals
  • Autoantibodies (immunology)
  • Autoimmune Diseases (immunology, physiopathology)
  • Epidermis (enzymology, physiopathology)
  • Female
  • Humans
  • Immunoglobulin G (immunology)
  • Infant, Newborn
  • Male
  • Organ Culture Techniques
  • Pemphigus (enzymology, immunology, physiopathology)
  • Plasminogen Activators (immunology, isolation & purification, physiology)
  • Rabbits
  • Skin Diseases (etiology)
  • Urokinase-Type Plasminogen Activator (immunology, isolation & purification, physiology)

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