Acute hepatitis in Crigler-Najjar syndrome.

Abstract

We describe a 23-yr-old man with congenital unconjugated hyperbilirubinemia secondary to uridine diphosphate glucuronosyltransferase deficiency, and who cannot readily be classified as type I or type II Crigler-Najjar syndrome. After an episode of kernicterus in childhood he was treated with phenobarbital with a resultant marked decrease in his serum bilirubin concentration. Herein we describe his course after developing acute hepatitis secondary to infectious mononucleosis. He was treated acutely with plasmapheresis with prevention of any neurological sequelae despite having previously suffered from kernicterus.

• Authors: A H Sherker, J Heathcote
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 82 Issue 9 Pg. 883-5 (Sep 1987) ISSN: 0002-9270 [Print] United States
• PMID: 3115090 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucuronosyltransferase

Topics

• Acute Disease
• Adult
• Crigler-Najjar Syndrome (complications, enzymology)
• Glucuronosyltransferase (deficiency)
• Hepatitis (complications, enzymology)
• Humans
• Hyperbilirubinemia, Hereditary (complications)
• Male