In vivo and in vitro modulation of growth hormone and prolactin of a mixed somatotropic-lactotropic pituitary microadenoma.

Abstract

Both in vivo and in vitro responses of prolactin and growth hormone to stimuli were studied in an acromegalic, amenorrheic woman with a chromophobe adenoma of the pituitary gland. Preoperative testing revealed a prolactin rise after thyrotropin-releasing hormone and chlorpromazine and a decline after L-dopa and bromocriptine administration. During 3.5-hour incubations, cultured tumor cells produced significant increases of growth hormone and prolactin after dibutyryl adenosine 3',5'-cyclic monophosphate stimulation, while bromocriptine inhibited both hormones.

• Authors: E K Muechler, K E Huang, J V McDonald, L Tang
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 157 Issue 2 Pg. 453-5 (Aug 1987) ISSN: 0002-9378 [Print] United States
• PMID: 3113252 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Bromocriptine
• Levodopa
• Thyrotropin-Releasing Hormone
• Prolactin
• Growth Hormone
• Chlorpromazine

Topics

• Adenoma, Chromophobe (metabolism)
• Adult
• Bromocriptine (pharmacology)
• Chlorpromazine (pharmacology)
• Depression, Chemical
• Female
• Growth Hormone (metabolism)
• Humans
• In Vitro Techniques
• Levodopa (pharmacology)
• Pituitary Neoplasms (metabolism)
• Prolactin (metabolism)
• Stimulation, Chemical
• Thyrotropin-Releasing Hormone (pharmacology)