S-100 protein positive cells in nasopharyngeal carcinoma (NPC): absence of prognostic significance. A clinicopathological and immunohistochemical study of 40 cases.

Abstract

An immunohistochemical study of S-100 protein in 43 nasopharyngeal carcinomas (NPC) of known clinical evolution (33 primary and 10 metastatic) is presented. Sixty per cent of primary site cases as well as all metastatic forms showed S-100 protein positive cells intermingled with tumour cells. These S-100 positive elements were identified as Langerhans cells. No significant differences were found when correlating S-100 protein positivity and histological NPC variants, neither in age nor in sex of patients. Statistical analysis failed to demonstrate any positive correlation between S-100 protein reactivity and clinical survival.

• Authors: F J Vera-Sempere, C Micheau, A Llombart-Bosch
• Journal: Virchows Archiv. A, Pathological anatomy and histopathology (Virchows Arch A Pathol Anat Histopathol) Vol. 411 Issue 3 Pg. 233-7 ( 1987) ISSN: 0174-7398 [Print] Germany
• PMID: 3113065 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neoplasm Proteins
• S100 Proteins

Topics

• Adolescent
• Adult
• Child
• Female
• Humans
• Immunologic Techniques
• Male
• Middle Aged
• Nasopharyngeal Neoplasms (pathology)
• Neoplasm Proteins (analysis)
• Prognosis
• S100 Proteins (analysis)