HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prompt relief of vasospastic angina by calcium antagonists.

Abstract
A 57-year-old man had recurrent episodes of angina pectoris at rest. An electrocardiogram (ECG) during attack revealed transient ST elevations in leads V1 to V5. His symptoms were not relieved by sublingual nitroglycerin (TNG), but subsided promptly following sublingual or intravenous calcium antagonists. However, there was no difference between the degree of ST elevation on ECG recorded during the treatment of angina with either TNG or with calcium antagonist. Recurrent angina and painless ST elevation on Holter ECG recordings were prevented by a large dose of diltiazem. Coronary arteriography revealed only mild stenosis at the proximal portion of the left anterior descending coronary artery. It is suggested that coronary artery spasm was the cause of angina in this case and that sublingual or intravenous calcium antagonist was more effective in the treatment of acute attack of vasospastic angina than sublingual TNG.
AuthorsK Egashira, H Araki, H Tomoike, A Takeshita, M Nakamura
JournalInternational journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 25 Issue 4 Pg. 175-7 (Apr 1987) ISSN: 0174-4879 [Print] Germany
PMID3108169 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Calcium Channel Blockers
  • Diltiazem
  • Nitroglycerin
Topics
  • Angina Pectoris, Variant (drug therapy, physiopathology)
  • Calcium Channel Blockers (therapeutic use)
  • Diltiazem (therapeutic use)
  • Electrocardiography
  • Humans
  • Male
  • Middle Aged
  • Nitroglycerin (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: