Suppression of hemoglobin H in disorders of iron metabolism.

Abstract

Disorders of iron metabolism affect the expression of hemoglobin H in hemoglobin H disease. Two cases of iron deficiency with reduced synthesis of hemoglobin H are described in the literature. We report two more cases, one with anemia of chronic disease and another with alcoholic sideroblastic anemia where the hemoglobin H was not detected at presentation and appeared after treatment of the underlying disorder. The pathogenesis of suppression of hemoglobin H is discussed.

• Authors: A Saleem, D R Irani, J B Bart, C P Alfrey Jr
• Journal: Acta haematologica (Acta Haematol) Vol. 77 Issue 1 Pg. 34-7 ( 1987) ISSN: 0001-5792 [Print] Switzerland
• PMID: 3107319 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hemoglobins, Abnormal
• Hemoglobin H
• Iron

Topics

• Adolescent
• Adult
• Alcohol Drinking
• Anemia, Hypochromic (blood, diagnosis)
• Anemia, Sideroblastic (blood, diagnosis)
• Chronic Disease
• Female
• Hemoglobin H (analysis, metabolism)
• Hemoglobins, Abnormal (metabolism)
• Humans
• Iron (metabolism)
• Iron Deficiencies