Abstract |
A study was made on the effect of undernutrition on the immunological responses of mice to TAB and BCG vaccines. The mice were fed a diet comprising chapati and germinated grams; one group was fed ad libitum while another was given half the quantity consumed by the first group. The undernourished mice showed a poor immune response to BCG: only 23% showed a positive reaction to foot pad challenge with purified protein derivative, compared with 76% of the well-fed mice. The mean increase in thickness of the foot pad was also significantly smaller in the undernourished mice. Antibody titres against the H and O antigens of TAB were essentially similar in both groups of mice. The results suggest that undernutrition depresses cell-mediated immune responses but not humoral responses.
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Authors | R B Narayanan, I Nath, U N Bhuyan, G P Talwar |
Journal | Bulletin of the World Health Organization
(Bull World Health Organ)
Vol. 56
Issue 5
Pg. 781-6
( 1978)
ISSN: 0042-9686 [Print] Switzerland |
PMID | 310720
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- BCG Vaccine
- Typhoid-Paratyphoid Vaccines
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Topics |
- Animals
- Antibody Formation
- BCG Vaccine
(immunology)
- Immunity, Cellular
- Male
- Mice
- Nutrition Disorders
(immunology)
- Typhoid-Paratyphoid Vaccines
(immunology)
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