[Cholestasis in total parenteral nutrition. A review].

Abstract

Intrahepatic cholestasis is a frequent, however, unresolved complication of total parenteral nutrition in infancy. A frequency of 10-50% is reported. The concentration of serum bile acids seems to be a sensitive indicator for a beginning cholestasis. As typical histological alterations of the liver are considered: inflammatory portal reaction, fibrosis and proliferation of bile ducts. As important components of the obviously multifactorial etiology are considered: lacking oral alimentation, fetal bile acid synthetic pathways, amino acid toxicity, hypoalbuminemia, sepsis and substrate excess.

• Authors: H Böhles
• Journal: Infusionstherapie und klinische Ernahrung (Infusionsther Klin Ernahr) Vol. 14 Suppl 1 Pg. 3-9 (Feb 1987) ISSN: 0378-0791 [Print] Switzerland
• Vernacular Title: Cholestase bei totaler parenteraler Ernährung (TPE). Eine Ubersicht.
• PMID: 3106211 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Bile Acids and Salts
• Fat Emulsions, Intravenous
• Serum Albumin
• Bilirubin

Topics

• Amino Acids (metabolism)
• Bile Acids and Salts (metabolism)
• Bilirubin (metabolism)
• Birth Weight
• Cholestasis, Intrahepatic (metabolism)
• Fat Emulsions, Intravenous (metabolism)
• Gestational Age
• Humans
• Infant
• Infant, Newborn
• Jaundice, Neonatal (metabolism)
• Parenteral Nutrition, Total
• Sepsis (metabolism)
• Serum Albumin (metabolism)