Abstract |
In 34 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for five years. Patients were included in the study only if the duration of their disease exceeded 6 months (upper limit 12 months), and there was involvement of 6 or more joints and an elevated erythrocyte sedimentation rate (1 Hour values greater than or equal to 25 mm). In 9 patients (26%) a decline in the activity index could be observed, but 7 of these subjects had a deterioration of findings as assessed by x-ray. The increase of the activity index indicated no therapeutic benefit in 25 patients (74%), which could be confirmed in all subjects by x-ray.
|
Authors | H Rautenstrauch, W Laschner, J G Saal, P Fritz |
Journal | Zeitschrift fur Rheumatologie
(Z Rheumatol)
1986 Nov-Dec
Vol. 45
Issue 6
Pg. 319-21
ISSN: 0340-1855 [Print] Germany |
Vernacular Title | Ergebnisse der D-Penicillamin-Langzeittherapie bei chronischer Polyarthritis. |
PMID | 3103349
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Aged
- Arthritis, Rheumatoid
(drug therapy)
- Female
- Humans
- Joints
(drug effects)
- Long-Term Care
- Male
- Middle Aged
- Penicillamine
(therapeutic use)
- Synovial Membrane
(drug effects)
|