I-Ad antigen expression of pyran copolymer-induced peritoneal cells in tumor vaccine-primed mice and its association with the host antitumor response.

Abstract	Mice inoculated IP with L1210 murine leukemia vaccine and subsequently with pyran copolymer-induced macrophages (pyran-M phi) lived for a prolonged time after live L1210 inoculation IP. Pyran-M phi as tentatively identified by anti-AcM.1 monoclonal antibody expressed I-Ad antigen in tumor vaccine-primed recipient mice and contributed to maintaining I-Ad antigen positive (I-Ad+) macrophages at high cell density in the peritoneal cavity of recipient mice. The relevance of these I-Ad+ cells to the host antitumor response was examined by experiments in which I-Ad+ cell density in the peritoneal cavity and host antitumor response behaved in a parallel fashion. Human interferon-alpha A/D, an agent selectively inhibiting Ia antigen expression, and silica, a general antimacrophage agent, strongly suppressed I-Ad antigen expression of peritoneal macrophages of tumor vaccine-primed and pyran-M phi-inoculated mice and, consistently with this, the antitumor response was nullified in these mice. Tumor vaccine-primed mice inoculated with sodium caseinate or thioglycollate-induced peritoneal cells did not survive L1210 inoculation and, in these mice, I-Ad+ peritoneal macrophages were suppressed in number as compared with those of tumor vaccine-primed and pyran-M phi-inoculated mice. These results warrant further study on the contribution of I-Ad+ macrophages to pyran copolymer-induced augmentation of the antitumor response in tumor vaccine-primed mice.
Authors	F Oh-hashi, T Kataoka, T Taniyama
Journal	Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 24 Issue 1 Pg. 57-63 ( 1987) ISSN: 0340-7004 [Print] Germany
PMID	3102063 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Histocompatibility Antigens Class II Polymers Vaccines Pyran Copolymer
Topics	Animals Cytotoxicity, Immunologic Genes, MHC Class II Histocompatibility Antigens Class II (analysis) Immunotherapy Leukemia L1210 (immunology, therapy) Macrophages (drug effects, immunology) Male Mice Mice, Inbred DBA Mice, Inbred Strains Polymers (pharmacology) Pyran Copolymer (pharmacology) Vaccines (administration & dosage)

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