[Antiviral and immunostimulating effect of maleic anhydride copolymers in experimental neuroviral infections].

The virus-inhibiting and immunostimulating activity of Soviet preparations, maleic anhydride copolymers, was demonstrated in alpha-, flavi-, and bunyavirus infections. Positive results were obtained in subcutaneous and intraperitoneal inoculations of the preparations used in prophylactic and therapeutic-prophylactic schedules. Stimulation of vaccination immunity was observed after combined use of copolymers and the vaccine against Eastern equine encephalomyelitis.
AuthorsA A Davydova, L L Stotskaia, L K Berezina, L V Osipova, I F Barinskiĭ
JournalVoprosy virusologii (Vopr Virusol) 1986 Sep-Oct Vol. 31 Issue 5 Pg. 595-8 ISSN: 0507-4088 [Print] USSR
Vernacular TitleProtivovirusnyĭ i immunostimuliruiushchiĭ éffekt sopolimerov maleinovogo angidrida pri éksperimental'nykh neĭrovirusnykh infektsiiakh.
PMID3099477 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Antiviral Agents
  • Furans
  • Maleic Anhydrides
  • Polymers
  • Viral Vaccines
  • Adjuvants, Immunologic (therapeutic use)
  • Animals
  • Antiviral Agents (therapeutic use)
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Encephalitis Virus, Eastern Equine (immunology)
  • Encephalitis Viruses, Tick-Borne (immunology)
  • Encephalitis, Tick-Borne (drug therapy, immunology, prevention & control)
  • Encephalomyelitis, Equine (drug therapy, immunology, prevention & control)
  • Furans (therapeutic use)
  • Hemorrhagic Fever Virus, Crimean-Congo (immunology)
  • Hemorrhagic Fever, Crimean (drug therapy, immunology, prevention & control)
  • Immunity (drug effects)
  • Maleic Anhydrides (therapeutic use)
  • Mice
  • Polymers (therapeutic use)
  • Viral Vaccines (therapeutic use)

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