Abstract |
The syndromes of severe undernutrition, marasmus and kwashiorkor, have causes related to the interplay of social and medical considerations in the society. Kwashiorkor supervenes when the individual is exposed to a level of stress that exceeds the body's ability to cope. One final common pathway, through which a variety of environmental factors exert an effect, may be associated with oxidant damage to cells. In kwashiorkor there is a severe decrease in the level of both oxidised and reduced glutathione in the red cell. This could be caused by a decreased production, increased consumption or a combination of the two. This is discussed with specific reference to the metabolism of glycine and the possible causal relationship to the pathophysiology of the disease process.
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Authors | A A Jackson |
Journal | Acta paediatrica Scandinavica. Supplement
(Acta Paediatr Scand Suppl)
Vol. 323
Pg. 43-51
( 1986)
ISSN: 0300-8843 [Print] Sweden |
PMID | 3092564
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Proteins
- Glutathione
- Glycine
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Topics |
- Developing Countries
- Dietary Proteins
(metabolism)
- Fatty Liver
(metabolism)
- Glutathione
(blood)
- Glycine
(metabolism)
- Humans
- Infant
- Jamaica
- Kwashiorkor
(epidemiology, metabolism)
- Protein-Energy Malnutrition
(epidemiology, metabolism)
- Weaning
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