Increased expression of the c-myc gene without gene amplification in human lung cancer and colon cancer cell lines.

Abstract

High levels of c-myc mRNA were observed in two human tumor cell lines, a giant cell carcinoma of the lung (C-Lu99) and a colon cancer (C1). The increased expression of c-myc in these cell lines, which was comparable with those in cell lines in which the c-myc gene is amplified, was not due to gene amplification. Run-on transcription revealed that the transcriptional rate of the c-myc gene was greatly increased in these cell lines.

• Authors: K Yoshimoto, S Hirohashi, T Sekiya
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 77 Issue 6 Pg. 540-5 (Jun 1986) ISSN: 0910-5050 [Print] Japan
• PMID: 3089986 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger

Topics

• Cell Line
• Colonic Neoplasms (genetics)
• Gene Amplification
• Gene Expression Regulation
• Humans
• Lung Neoplasms (genetics)
• Oncogenes
• RNA, Messenger (analysis)
• Recombination, Genetic
• Transcription, Genetic