Influence of dosing interval and in-patient versus out-patient status on incidence of side-effects of niridazole.

Abstract

The side-effects of niridazole used for urinary schistosomiasis were studied prospectively over a 3-month period in male patients receiving the standard dose of 25 mg day-1 kg-1 for 7 days. Side-effects were detected in 80% of in-patients but only in 33% of out-patients. The range of side-effects was greater in in-patients taking their daily doses in two portions than in those taking theirs in three. Cure rates and degree of schistosoma egg suppression were significantly lower in out-patients suggesting that compliance with treatment was poorer.

• Authors: I Abdu-Aguye, L Sambo-Donga
• Journal: Human toxicology (Hum Toxicol) Vol. 5 Issue 4 Pg. 275-8 (Jul 1986) ISSN: 0144-5952 [Print] England
• PMID: 3089911 (Publication Type: Journal Article)

Chemical References

• Niridazole

Topics

• Adolescent
• Adult
• Child
• Humans
• Inpatients
• Male
• Niridazole (administration & dosage, adverse effects)
• Outpatients
• Patient Compliance
• Prospective Studies
• Schistosomiasis haematobia (drug therapy)