Assessment of oral candidiasis in patients with respiratory disease and efficacy of a new nystatin formulation.

Fifty consecutive patients with respiratory diseases who developed oropharyngeal candidiasis were assessed clinically and microbiologically before and after seven days' treatment with nystatin suspension or pastilles (a new formulation). In 45 patients in whom microbiology yielded positive results there was frequent associated use of oral corticosteroids, antibiotics, sedatives, and inhaled corticosteroid, while in a few patients atropine analogues may have predisposed to infection. Dentures were worn by 32 of the infected patients. Concomitant treatment of dentures in chronically infected patients appeared to improve the therapeutic response. Pastilles and suspension were equally efficacious both clinically and microbiologically. The potential for enhanced drug delivery to the oropharynx suggests that nystatin pastilles may be useful in patients in whom poor compliance seems likely.
AuthorsP J Thompson, H J Wingfield, R F Cosgrove, B O Hughes, M E Turner-Warwick
JournalBritish medical journal (Clinical research ed.) (Br Med J (Clin Res Ed)) Vol. 292 Issue 6537 Pg. 1699-700 (Jun 28 1986) ISSN: 0267-0623 [Print] ENGLAND
PMID3089361 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Steroids
  • Tablets
  • Nystatin
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (adverse effects)
  • Candidiasis, Oral (complications, drug therapy)
  • Dentures
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nystatin (administration & dosage, therapeutic use)
  • Respiratory Tract Diseases (complications)
  • Respiratory Tract Neoplasms (complications)
  • Steroids (adverse effects)
  • Tablets

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