Safety and efficacy of once daily ceftriaxone for the treatment of bacterial meningitis.

Abstract

Fifty-seven patients with bacterial meningitis were treated with once daily ceftriaxone. After an initial loading dose of 100 mg/kg, the patients received 80 mg/kg as a single daily dose. Etiologic agents included: Haemophilus influenzae type b, 37 (11 beta-lactamase-positive); Neisseria meningitidis, 11; Streptococcus pneumoniae, 6; Streptococcus pyogenes, 1; Haemophilus influenzae type f, 1; and Group B Streptococcus, 1. All patients showed clinical improvement and all were bacteriologically cured. Satisfactory cerebrospinal fluid bactericidal activity and drug concentrations were seen 24 hours after a dose even in those patients in whom repeat spinal taps were carried out following the last dose of therapy. The drug was well-tolerated and the major adverse effect seen was diarrhea in 20.4% of the patients. The diarrhea was mild and self-limited and did not necessitate discontinuation of the drug although it was frequently associated with alterations in the stool microbiologic flora. Based on this preliminary experience, ceftriaxone, when given in a single daily dose, appears safe and effective in the treatment of bacterial meningitis in nonneonatal infants and children.

• Authors: B L Congeni, J Bradley, M R Hammerschlag
• Journal: Pediatric infectious disease (Pediatr Infect Dis) 1986 May-Jun Vol. 5 Issue 3 Pg. 293-7 ISSN: 0277-9730 [Print] United States
• PMID: 3088548 (Publication Type: Journal Article)

Chemical References

• Ceftriaxone

Topics

• Bacterial Infections (cerebrospinal fluid, drug therapy, microbiology)
• Ceftriaxone (administration & dosage, adverse effects, cerebrospinal fluid, therapeutic use)
• Child
• Child, Preschool
• Diarrhea (chemically induced)
• Feces (microbiology)
• Female
• Haemophilus influenzae (drug effects)
• Humans
• Infant
• Infant, Newborn
• Male
• Meningitis (cerebrospinal fluid, drug therapy, microbiology)
• Meningitis, Haemophilus (cerebrospinal fluid, drug therapy, microbiology)
• Meningitis, Meningococcal (cerebrospinal fluid, drug therapy, microbiology)
• Meningitis, Pneumococcal (cerebrospinal fluid, drug therapy, microbiology)
• Neisseria meningitidis (drug effects)
• Streptococcus agalactiae (drug effects)
• Streptococcus pneumoniae (drug effects)
• Streptococcus pyogenes (drug effects)