Implanted vascular access device related deep vein thrombosis in oncology patients: A prospective cohort study.

Implanted vascular access devices (IVADs) have significantly improved the management of cancer patients. These patients are at an increased risk of venous thromboembolism and IVADs are a known risk factor. We sought to assess the incidence of IVAD-related upper extremity deep vein thrombosis (IVAD-related UEDVT) associated with BioFlo® IVADs (Angiodynamics, Inc.).
A total of 394 cancer patients were enrolled over 12 months. The primary outcome was the incidence of IVAD-related UEDVT confirmed by diagnostic imaging. IVAD-related UEDVT was defined as symptomatic ipsilateral upper extremity (axillary vein or proximal) deep vein thrombosis and symptomatic pulmonary embolism (PE). Patients were followed until initiation of therapeutic anticoagulation, catheter removal, death, or up to 12 months.
389 patients were included in the analysis. The median age of the cohort was 58.2 years; 68% (n = 273) were females. Sixty-six percent had gastrointestional cancer (including pancreatic cancer) and 68% had metastases. Eighty four percent of IVADs were right sided insertions. Ninety eight percent of catheter tip placements were distal superior vena cava (n = 237), cavo-atrial junction (n = 67) or atrium (n = 90). Overall, 5 patients had symptomatic IVAD-related UEDVT (1.29%, 95% CI 0.2 to 2.4%).
IVAD-related UEDVT is an infrequent complication in cancer patients with BioFlo® IVADs.
AuthorsAdam Suleman, Virginia Jarvis, Adnan Hadziomerovic, Marc Carrier, Sheryl McDiarmid
JournalThrombosis research (Thromb Res) Vol. 177 Pg. 117-121 (May 2019) ISSN: 1879-2472 [Electronic] United States
PMID30875491 (Publication Type: Journal Article)
CopyrightCopyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Neoplasms (complications)
  • Prospective Studies
  • Vascular Access Devices (adverse effects)
  • Venous Thrombosis (diagnosis, etiology)
  • Young Adult

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