Transcatheter vascular occlusion therapy with isobutyl 2-cyanoacrylate (bucrylate) for control of massive upper-gastrointestinal bleeding.

Abstract

Transcatheter embolization with bucrylate, a tissue adhesive, was performed in 16 patients with massive upper-gastrointestinal bleeding. Control of arterial bleeding from the stomach was achieved in 6 of 8 patients, and from the duodenum in 3 of 4. Embolization of gastric veins resulted in temporary control of esophageal variceal bleeding in 3 of 4 patients. Histological study showed no evidence of bucrylate causing histotoxicity in 2 patients. Because bucrylate polymerizes rapidly, a localized vascular occlusion mimicking a surgical ligation is produced. Because collateral vessels are not occluded. localized tissue ischemia is unlikely. Tissue adhesives are, however, difficult to use.

• Authors: M L Goldman, P C Freeny, J M Tallman, J T Galambos, E L Bradley 3rd, A Salam, K T Oen, I J Gordon, R Mennemeyer
• Journal: Radiology (Radiology) Vol. 129 Issue 1 Pg. 41-9 (Oct 1978) ISSN: 0033-8419 [Print] United States
• PMID: 308668 (Publication Type: Journal Article)

Chemical References

• Cyanoacrylates
• Bucrylate

Topics

• Adult
• Aged
• Bucrylate (administration & dosage, adverse effects, therapeutic use)
• Catheterization
• Cyanoacrylates (therapeutic use)
• Drug Evaluation
• Embolization, Therapeutic (methods)
• Esophageal and Gastric Varices (complications, diagnostic imaging)
• Female
• Gastrointestinal Hemorrhage (diagnostic imaging, therapy)
• Humans
• Male
• Middle Aged
• Peptic Ulcer Hemorrhage (diagnostic imaging, therapy)
• Radiography