Hypercalcemia and reversible renal failure in heavy-chain disease.

Abstract

We have reported a case of gamma heavy-chain disease associated with hypercalcemia and reversible renal failure. After combined chemotherapy the patient remains well after 21 months of follow-up, and serum calcium levels remain in the normal range. This case supports the notion of Kyle et al that heavy-chain disease may present a diverse picture, and documents the first use of aggressive combination chemotherapy in the management of associated moderately severe hypercalcemia and hypercalcemic renal failure.

• Authors: S B Eisner, P D Mitnick
• Journal: Southern medical journal (South Med J) Vol. 79 Issue 4 Pg. 507-9 (Apr 1986) ISSN: 0038-4348 [Print] United States
• PMID: 3085235 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin gamma-Chains
• Vincristine
• Cyclophosphamide
• Calcium
• Prednisone

Topics

• Acute Kidney Injury (etiology)
• Aged
• Calcium (blood)
• Cyclophosphamide (administration & dosage)
• Diagnosis, Differential
• Drug Therapy, Combination
• Heavy Chain Disease (complications, diagnosis)
• Humans
• Hypercalcemia (drug therapy, etiology)
• Immunoglobulin gamma-Chains (analysis)
• Kidney Diseases (drug therapy)
• Male
• Melanoma (diagnosis)
• Prednisone (administration & dosage)
• Time Factors
• Vincristine (administration & dosage)