Induction and growth of mammary tumors after superior cervical ganglionectomy in sighted and blinded-anosmic rats.

Female rats were subjected to superior cervical ganglionectomy (Gx), blinding and anosmia (BAs) or combined procedures (BAsGx). Onset and growth of dimethylbenz(a)anthracene (DBMA)-induced mammary tumors was studied in these animals and compared to tumorigenesis in intact control rats. Carcinostatic effects were present in all surgically altered animals, as evidenced by a trend toward reduced tumor incidence, reduced final tumor mass, and a significant reduction in mean number of tumors in Gx and BAsGx rats, and increased regression of tumors in BAs rats compared to intact group. Reduced tumorigenesis was paralleled by a trend toward either an increase (BAs) or a decrease (Gx and BAsGx) in the activity of pineal hydroxyindole-O-methyltransferase (HIOMT) compared to intact group. In addition, BAs and BAsGx animals showed a significant reduction in body weight. These results suggest that Gx reduces mammary tumorigenesis in both sighted and BAs rats. They further confirm the findings of others on reduced mammary tumorigenesis in BAs rats. Possible involvement of multiple carcinostatic mechanisms in different animal models is discussed.
AuthorsN Chang, M T Tseng, T S Spaulding
JournalLife sciences (Life Sci) Vol. 38 Issue 20 Pg. 1821-6 (May 19 1986) ISSN: 0024-3205 [Print] ENGLAND
PMID3084898 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 9,10-Dimethyl-1,2-benzanthracene
  • Acetylserotonin O-Methyltransferase
  • Melatonin
  • 9,10-Dimethyl-1,2-benzanthracene
  • Acetylserotonin O-Methyltransferase (analysis)
  • Animals
  • Female
  • Hypothalamus (blood supply)
  • Mammary Neoplasms, Experimental (etiology, pathology)
  • Melatonin (pharmacology)
  • Olfaction Disorders (metabolism)
  • Pineal Gland (physiology)
  • Rats
  • Rats, Inbred Strains
  • Sensory Deprivation
  • Stress, Physiological (metabolism)
  • Sympathectomy
  • Vision, Ocular

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: