[Clinical studies on doxycycline in the treatment of nongonococcal urethritis by Chlamydia trachomatis].

Abstract

Twenty-one nongonococcal urethritis patients by Chlamydia trachomatis infection were treated with doxycycline (DOXY, Vibramycin) 200 mg/day orally for 2 weeks. The age of these patients were ranged from 17 to 52. C. trachomatis was eradicated 8(89%) of 9 cases on 3rd day and never reisolated on 7th day after treatment. Ten (83%) of 12 patients on 7th day and any patients on 14th day were not suffered from symptoms after treatment. Urethral discharge was not seen macroscopically, 11 (92%) of 12 patients on 7th day and any patients on 14th day. According to the criteria for urethritis requiring at least 4 WBC per high power field in urethral smear and/or first voided urine, the overall clinical efficacy rate was 44% (4/9) on 3rd day, 83% (10/12) on 7th day and 100% (9/9) on 14th day. No side effects were recognized in any cases. In conclusion, DOXY was thought to be useful and safe drug in the treatment of nongonococcal urethritis by C. trachomatis.

• Authors: Y Ito, N Katoh, A Takeda, M Kanematsu, Y Ban, T Nishiura, S Sakai, S Fujihiro, T Doi, K Tei
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 39 Issue 1 Pg. 9-16 (Jan 1986) ISSN: 0368-2781 [Print] Japan
• PMID: 3084830 (Publication Type: Journal Article)

Chemical References

• Doxycycline

Topics

• Adolescent
• Adult
• Chlamydia Infections (drug therapy)
• Chlamydia trachomatis (isolation & purification)
• Doxycycline (therapeutic use)
• Follow-Up Studies
• Gonorrhea (drug therapy)
• Humans
• Male
• Middle Aged
• Neisseria gonorrhoeae (isolation & purification)
• Pyuria (drug therapy)
• Time Factors
• Urethritis (drug therapy)
• Urine (microbiology)