Prevention of superficial phlebitis during peripheral parenteral nutrition.

Abstract

Fifty-four patients receiving peripheral parenteral nutrition consisting of 3.5 percent amino acids in a 5 percent dextrose solution were randomly assigned in a double-blind fashion to receive this solution with or without an antiphlebitic mixture (1000 IU heparin, 5 mg hydrocortisone, and 1.8 mEq sodium hydroxide as a buffer). The addition of antiphlebitic mixture resulted in a marked and highly significant reduction in the incidence of phlebitis and a prolongation of the number of phlebitis-free hours during infusion of peripheral parenteral nutrition (p less than 0.005).

• Authors: P A Makarewicz, J B Freeman, R Fairfull-Smith
• Journal: American journal of surgery (Am J Surg) Vol. 151 Issue 1 Pg. 126-9 (Jan 1986) ISSN: 0002-9610 [Print] United States
• PMID: 3080920 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acids
• Sodium Hydroxide
• Heparin
• Glucose
• Hydrocortisone

Topics

• Aged
• Amino Acids (administration & dosage)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Glucose (administration & dosage)
• Heparin (administration & dosage)
• Humans
• Hydrocortisone (administration & dosage)
• Hydrogen-Ion Concentration
• Male
• Middle Aged
• Parenteral Nutrition (adverse effects)
• Phlebitis (prevention & control)
• Random Allocation
• Sodium Hydroxide (administration & dosage)
• Time Factors