Upper airway occlusion during sleep in patients with Cheyne-Stokes respiration.

Abstract

Sleep-induced periodic breathing has been suggested to lead to the development of occlusive apneas in patients with sleep apnea syndrome. If this were true, patients with Cheyne-Stokes respiration should also develop upper airway occlusion during sleep. To study this hypothesis, 6 nonobese patients with Cheyne-Stokes respiration lacking evidence for sleep apnea syndrome and anatomic upper airway abnormalities underwent polysomnography during daytime naps. A total of 463 apneas were analyzed in the 6 patients studied. In 1 patient, no evidence of upper airway occlusion was observed. In the remaining 5 patients, a varying frequency of upper airway occlusion resembling the pattern of mixed apnea was seen in 3 to 97% of the total apneas analyzed. The mean number (+/- 1 SD) of occluded inspiratory efforts per mixed apnea in these 5 patients was 1.69 +/- 0.59. These results show that patients with Cheyne-Stokes respiration may develop upper airway occlusion during sleep and are consistent with the contention that sleep-induced periodic breathing in patients with sleep apnea syndrome is primary to the development of occlusive apneas.

• Authors: C G Alex, E Onal, M Lopata
• Journal: The American review of respiratory disease (Am Rev Respir Dis) Vol. 133 Issue 1 Pg. 42-5 (Jan 1986) ISSN: 0003-0805 [Print] United States
• PMID: 3079976 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Carbon Dioxide
• Oxygen

Topics

• Carbon Dioxide (metabolism)
• Cheyne-Stokes Respiration (complications, physiopathology)
• Female
• Forced Expiratory Volume
• Humans
• Hydrogen-Ion Concentration
• Male
• Middle Aged
• Oxygen (metabolism)
• Pulmonary Ventilation
• Respiration Disorders (complications)
• Sleep Apnea Syndromes (etiology, physiopathology)
• Vital Capacity