[Collagen type I, III, IV and V and fibronectin in skin biopsies of patients with Ehlers-Danlos syndrome and cutis laxa].

Abstract

Immunofluorescence was employed to study distribution of collagen type I, III, IV and V, and fibronectin in skin biopsy specimens from patients with Ehlers-Danlos syndrome (EDS) and cutis laxa. Abnormal distribution of collagen type V in the skin biopsies was found out in EDS type VII. A high level of dermal fibronectin occurred in EDS type III. Tissue fibronectin was absent in the skin extracellular matrix in EDS type X. Defective distribution of collagen, predominantly of type III and V and fibronectin absence were registered in the skin connective tissue in cutis laxa.

• Authors: B V Shekhonin, A N Semiachkina, Kh M Makkaev, S P Domogatskiĭ, G L Idel'son
• Journal: Arkhiv patologii (Arkh Patol) Vol. 50 Issue 12 Pg. 41-8 ( 1988) ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Kollagen I, III, IV, V tipov i fibronektin v bioptatkh kozhi bol'nykh s sindromami Elersa-Danlo i cutis laxa.
• PMID: 3074749 (Publication Type: English Abstract, Journal Article)

Chemical References

• Fibronectins
• Collagen

Topics

• Biopsy
• Collagen (analysis)
• Cutis Laxa (metabolism, pathology)
• Ehlers-Danlos Syndrome (metabolism, pathology)
• Extracellular Matrix (analysis)
• Fibronectins (analysis)
• Fluorescent Antibody Technique
• Humans
• Skin (analysis, pathology)