Clinical evaluation of S-CMC syrup applied in the treatment of otitis media with effusion. Double blind comparative test with placebo.

Abstract

We carried out a double blind comparative trial with placebo serving as control using 250 cases of infant otitis media with effusion (OME) in order to objectively evaluate the clinical usefulness of S-carboxymethylcysteine (S-CMC), an oral mucolytic agent, against OME. The results obtained were as follows. 1) Global improvement rate, when judged in items of overall improvement, was 79.8% in S-CMC group and 58.2% in placebo group, S group being significantly better when compared to P. 2) The degree of improvement in each item for evaluation revealed significantly better results in S group compared to P, in both objective findings of the effusion amount and its property, and in audiological findings. 3) Adverse reactions observed in 3 cases (2.5%) in S group and in 2 (1.5%) in P group were not serious, and were eliminated through suspension or discontinuation of the medication. The results obtained suggested the usefulness of S-CMC when used in the treatment of OME.

• Authors: T Kumazawa, K Ushiro
• Journal: Acta oto-laryngologica. Supplementum (Acta Otolaryngol Suppl) Vol. 458 Pg. 56-62 ( 1988) ISSN: 0365-5237 [Print] Norway
• PMID: 3072830 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Carbocysteine
• Cysteine

Topics

• Administration, Oral
• Carbocysteine (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Cysteine (analogs & derivatives)
• Double-Blind Method
• Female
• Humans
• Japan
• Male
• Multicenter Studies as Topic
• Otitis Media with Effusion (drug therapy)