HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Effectiveness and side effects of recombinant alpha-2a interferon in patients with metastatic hypernephroma].

Abstract
Eighteen patients with advanced renal cell carcinoma were treated with recombinant interferon alpha-2a (18 million IU s.c. three times a week). 9 patients had received prior hormonal therapy (tamoxifen). On entering the therapeutic schedule with recombinant interferon alpha-2a, all patients had progressive disease with multiple metastases. Flu-like symptoms occurred in general; they were severe in 9 cases. An impairment of the liver was shown by a rise of SGOT/SGPT and alkaline phosphatase in 2 patients, the gamma-GT was raised in 7 patients. The kidney function worsened in 3 cases. A fall in blood cell counts was seen in 8 cases. Five patients developed a transient stomatitis. Five patients (5/18) showed stable disease with the longest response duration of 17 months. One patient showed a complete remission 5 months after starting therapy for a duration of 7 months until now. Both the limited benefit from this treatment as well as some severe side effects indicate the need for further special evaluation and possible improvements of this therapeutic approach.
AuthorsF W Hirsch, B Kraaz, G W Löhr, K J Bross
JournalOnkologie (Onkologie) Vol. 11 Issue 6 Pg. 263-5 (Dec 1988) ISSN: 0378-584X [Print] Switzerland
Vernacular TitleWirksamkeit und Nebenwirkungen von rekombiniertem Interferon alpha-2a bei Patienten mit metastasierendem Hypernephrom.
PMID3071761 (Publication Type: Journal Article)
Chemical References
  • Interferon Type I
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
Topics
  • Adult
  • Aged
  • Carcinoma, Renal Cell (mortality, therapy)
  • Combined Modality Therapy
  • Follow-Up Studies
  • Humans
  • Injections, Subcutaneous
  • Interferon Type I (therapeutic use)
  • Interferon alpha-2
  • Interferon-alpha (adverse effects, therapeutic use)
  • Kidney Neoplasms (mortality, therapy)
  • Middle Aged
  • Neoplasm Metastasis
  • Recombinant Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: