von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

Abstract

Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose density gradient ultracentrifugation, and crossed immunoelectrophoresis. They show reactions of immunologic nonidentity with each other, and thus, do not share a precursor-product relationship. vWagII is released from normal platelets during blood clotting, accounting for a fourfold higher concentration of vWagII in serum over plasma.

• Authors: R R Montgomery, T S Zimmerman
• Journal: The Journal of clinical investigation (J Clin Invest) Vol. 61 Issue 6 Pg. 1498-507 (Jun 1978) ISSN: 0021-9738 [Print] United States
• PMID: 307007 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens
• von Willebrand Factor

Topics

• Antigens (analysis)
• Blood Coagulation
• Blood Platelets (immunology)
• Centrifugation, Density Gradient
• Chromatography, Gel
• Humans
• Immunoelectrophoresis, Two-Dimensional
• Molecular Weight
• Plasma (immunology)
• von Willebrand Diseases (blood, immunology)
• von Willebrand Factor (analysis)