Effective and safe therapy with coenzyme Q10 for cardiomyopathy.

Abstract

Coenzyme Q10 (CoQ10) is indispensable in mitochondrial bioenergetics and for human life to exist. 88/115 patients completed a trial of therapy with CoQ10 for cardiomyopathy. Patients were selected on the basis of clinical criteria, X-rays, electrocardiograms, echocardiography, and coronary angiography. Responses were monitored by ejection fractions, cardiac output, and improvements in functional classifications (NYHA). Of the 88 patients 75%-85% showed statistically significant increases in two monitored cardiac parameters. Patients with the lowest ejection fractions (approx. 10%-30%) showed the highest increases (115 delta %-210 delta %) and those with higher ejection fractions (50%-80%) showed increases of approx. 10 delta %-25 delta % on therapy. By functional classification, 17/21 in class IV, 52/62 in class III, and 4/5 in class II improved to lower classes. Clinical responses appeared over variable times, and are presumably based on mechanisms of DNA-RNA-protein synthesis of apoenzymes which restore levels of CoQ10 enzymes in a deficiency state. 10/21 (48%) of patients in class IV, 26/62 (42%) in class III, and 2/5 (40%) in class II had exceptionally low control blood levels of CoQ10. Clinical responses on therapy with CoQ10 appear maximal with blood levels of approx. 2.5 micrograms CoQ10/ml and higher during therapy.

• Authors: P H Langsjoen, K Folkers, K Lyson, K Muratsu, T Lyson, P Langsjoen
• Journal: Klinische Wochenschrift (Klin Wochenschr) Vol. 66 Issue 13 Pg. 583-90 (Jul 01 1988) ISSN: 0023-2173 [Print] Germany
• PMID: 3062263 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Coenzymes
• Ubiquinone
• coenzyme Q10

Topics

• Adult
• Aged
• Aged, 80 and over
• Cardiac Output (drug effects)
• Cardiomyopathies (drug therapy)
• Cardiomyopathy, Dilated (drug therapy)
• Clinical Trials as Topic
• Coenzymes
• Coronary Disease (drug therapy)
• Female
• Heart Failure (drug therapy)
• Humans
• Male
• Middle Aged
• Stroke Volume (drug effects)
• Ubiquinone (analogs & derivatives, therapeutic use)