Abstract |
The effect of treatment with danazol (n = 10) or gonadotropin-releasing hormone agonists ( GnRH-a) (n = 10) on autoantibody (AA) production ( IgG, IgM and, IgA to 6 phospholipids, 5 histones, and 4 polynucleotides) in endometriosis was evaluated blindly in a longitudinal, prospective, randomized study. Clinical improvement, ovarian suppression, and resolution of endometriosis were comparable in both groups. Approximately 50% of patients had significant AA abnormalities initially. During treatment with danazol but not GnRH-a, AA gradually decreased in concentration and in number/patient. Total immunoglobulin levels ( IgG, IgM, and IgA) also decreased only in the danazol group. This study indicates that danazol, but not GnRH-a, lowers abnormal AA associated with endometriosis.
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Authors | A el-Roeiy, W P Dmowski, N Gleicher, E Radwanska, L Harlow, Z Binor, I Tummon, R G Rawlins |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 50
Issue 6
Pg. 864-71
(Dec 1988)
ISSN: 0015-0282 [Print] United States |
PMID | 3060379
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Autoantibodies
- Immunoglobulins
- Pituitary Hormone-Releasing Hormones
- Pregnadienes
- Danazol
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Topics |
- Adult
- Antibody Formation
(drug effects)
- Autoantibodies
(analysis)
- Danazol
(pharmacology)
- Depression, Chemical
- Endometriosis
(immunology)
- Female
- Humans
- Immunoglobulins
(analysis)
- Pituitary Hormone-Releasing Hormones
(pharmacology)
- Pregnadienes
(pharmacology)
- Pregnancy
- Pregnancy Outcome
- Random Allocation
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