A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl).

Abstract

A single-blind crossover study was used to compare the ability of a 0.2% chlorhexidine mouthrinse (Corsodyl) with a sanguinarine-zinc mouthrinse (Veadent) to inhibit plaque and gingivitis. 14 volunteers starting with plaque-free mouths and optimal gingival health, rinsed with the preparations over two 19-day periods whilst refraining from all other oral hygiene procedures. At days 8, 15 and 19 of the trial, Corsodyl was significantly more effective at inhibiting both plaque and gingivitis. The findings of this study would suggest that the Veadent mouthrinse would at most only have a limited rôle as an inhibitor of plaque and gingivitis.

• Authors: J Moran, M Addy, R Newcombe
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 15 Issue 10 Pg. 612-6 (Nov 1988) ISSN: 0303-6979 [Print] United States
• PMID: 3058752 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Benzophenanthridines
• Isoquinolines
• Mouthwashes
• sanguinarine
• Zinc
• Chlorhexidine

Topics

• Adult
• Alkaloids (administration & dosage)
• Benzophenanthridines
• Chlorhexidine (administration & dosage)
• Clinical Trials as Topic
• Dental Plaque (prevention & control)
• Female
• Gingivitis (prevention & control)
• Humans
• Isoquinolines
• Male
• Mouthwashes (therapeutic use)
• Random Allocation
• Zinc (administration & dosage)